Adenoviral-Mediated Placental Gene Transfer of IGF-1 Corrects Placental Insufficiency via Enhanced Placental Glucose Transport Mechanisms

Adenoviral-Mediated Placental Gene Transfer of IGF-1 Corrects Placental Insufficiency via Enhanced Placental Glucose Transport Mechanisms

UNLABELLED Previous work in our laboratory demonstrated that over-expression of human insulin-like growth factor -1 (hIGF-1) in the placenta corrects fetal weight deficits in mouse, rat, and rabbit models of intrauterine growth restriction without changes in placental weight. The underlying mechanisms of this effect have not been elucidated. To investigate the effect of intra-placental IGF-1 ov...

Mechanisms Involved in the Placental Glucose Transfer

The mechanisms involved in both placental uptake and transfer of macronutrients are reviewed. Fatty acid, cholesterol and amino acid transport across the placenta involves a complex system to ensure nutrient delivery to the growing fetus. The placental glucose transfer is important for fetal macrosomia, but lipid disturbances in both maternal and placental compartments may contribute to neonata...

Placental Insufficiency.

What factors determine placental glucose transfer kinetics?☆

INTRODUCTION Transfer of glucose across the human placenta is directly proportional to maternal glucose concentrations even when these are well above the physiological range. This study investigates the relationship between maternal and fetal glucose concentrations and transfer across the placenta. METHODS Transfer of d-glucose, (3)H-3-o-methyl-d-glucose ((3)H-3MG) and (14)C-l-glucose across ...

The histopathology of placental insufficiency.

Voltaire, regarded by some as a realist and by others as a cynic, remarked that 'if God did not exist it would be necessary to invent him'. One suspects that this comment is equally applicable to placental insufficiency, a concept that has similarly attracted not only faithful adherence but also bewildered agnosticism or defiant disbelief. Placental insufficiency has been largely defined in cli...